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KMID : 1023120100080020107
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Korean Journal of Aesthetic Society
2010 Volume.8 No. 2 p.107 ~ p.116
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Antimicrobial Activity and Antioxidative Effects of Juniperus chinensis and Protective Effects on Human HaCaT Keratinocyte
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Ryu Min-Jeong
Lee Sook-young
Cho Sang-Hyeok
Park Yeol
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Abstract
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This Study was carried out to investigate antimicrobial activity and antioxidative effects of Juniperus chinensis and protective effects on Human HaCaT Keratinocyte. The antimicrobial activity of Juniperus chinensis extracts using a paper disc method and using four human scalp, skin pathogens. The antioxidative of extracts was used the method of DPPH radical, total polyphenolics and flavonoid contents. Protective effects of Juniperus chinensis on HaCaT keratinocytes against oxidative stree induced by hydrogen peroxide were also measured. In our results antimicrobial activity of Juniperus chinensis extracts was the strongest activity on P. acnes. In addition with Juniperus chinensis did show cytotoxicity on HaCat keratinocyte beneath the concentration elevated in dose -dependen. DPPH free radical scavening activities of Juniperus chinensis were elevated in dose dependent manner. In addition, The value of half maximal inhibitiory concentration(IC50) was 153.8±0.49 ㎍/㎖. 84.9 ± 0.01 ㎍/㎖ of total phenolics and 66.4± 0.02 ㎍/㎖ of flavonoids. Finally Juniperus chinensis showed protective effect against cell dath of HaCaT cell tnduced by hydrogen peroxide significantiy. In conclusion. these results suggest that Juniperus chinensis extracts may have antibioticl, antioxantic action on human scalp, skin and sugest the possibility as cosmetic material
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KEYWORD
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Scalp, Skin Pathogens, Antimicrobial, Antioxidative, Human HaCaT Keratinocyte
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